![]() Deuterated EDTA is available, but this is quite expensive. ![]() However, the use of EDTA introduces a number of 1H NMR signals for the free form as well as the Ca- and Mg-bound chelate forms. Chelation of the divalent metals with EDTA has been used with promising results (Asiago et al. A potential problem with this approach however may be the degradation of pH sensitive metabolites through hydrolysis or redox reactions.Ī number of approaches have been proposed to remove the divalent metal ions from urine samples and therefore remove their influence on metabolite peak chemical shifts. 2011 Lehnert and Hunkler 1986 Sze and Jardetzky 1994 Wevers et al. An alternative approach to minimise pH-dependent shifts is to move the sample pH to extreme values away from metabolite p K a values and towards the acid/base chemical shift limits (Beneduci et al. In addition, very salty samples reduce NMR sensitivity, especially for cryogenically cooled probes. While the use of a strong buffer may limit many metabolite peaks chemical shifts, a small number of metabolites, such as citrate and histidine, still exhibit strong inter-sample chemical shift variations (Lindon et al. ( 2009) recommended using 1.5 M buffer solutions in a 1:10 volume ratio of urine. 2007) recommended a minimum final concentration of 0.3 M for normal urine, and 1 M for concentrated urine samples. Buffers are commonly added to urine samples to control the pH variation of different samples. 2008).Ī number of studies have investigated different sample preparation techniques in order to limit the pH and metal ion dependent NMR peak position variation. The main metal ions present in urine are sodium, potassium, and the divalent ions calcium and magnesium, however it is the divalent ions that are the main contributors (after pH) to peak chemical shift variability (Ackerman et al. However, differences in its other components (such as urea, salts and other ions) are common, and result in often large variations in metabolite peak chemical shifts (Lindon et al. Urine is a popular biofluid used for metabolomic investigations, as it consists of various metabolites that can provide insight into a number of metabolic processes and disease states (Lindon et al. However, metabolite chemical shifts are sensitive to the chemical environment and subtle matrix effects, such as differences in pH and ionic strength, generally lead to inter-sample peak position variation (Weljie et al. 1H NMR is widely used for the metabolomic analysis of biofluids, as it provides quantitative, structural information on a wide range of metabolites, in a non-destructive and highly reproducible manner (Nicholson and Wilson 1989 Wishart 2008 Zhang et al.
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![]() Unless you have a gigantic whiteboard knocking around, you're limited to a fairly small piece of paper. You just start drawing and go from there with almost nothing in your way. Mind mapping with a sheet of paper and a pen is an incredibly intuitive and natural way to work. For more details on our process, read the full rundown of how we select apps to feature on the Zapier blog. We're never paid for placement in our articles from any app or for links to any site-we value the trust readers put in us to offer authentic evaluations of the categories and apps we review. We spend dozens of hours researching and testing apps, using each app as it's intended to be used and evaluating it against the criteria we set for the category. Who'd have thought before we started brainstorming that Alice Cooper flipping burgers at a family BBQ (or maybe in a fast food joint?) could make for a killer summer ad? What makes for great mind map software?Īll of our best apps roundups are written by humans who've spent much of their careers using, testing, and writing about software. "Family time" could also link to "Good weather" and "Vacation." "Burgers" could link to "Summer jobs." But by getting all these branching concepts down on paper, you can start to see the relationships between different things and generate new ideas. Some ideas will also connect back to other ideas. "BBQs" might lead to "Family time," "Good food," and "Burgers." "School's out" could lead to "Summer jobs," "Extracurriculars," and "Alice Cooper." For example, if the central theme was "Summer" (say, for a marketing campaign), the first five or so nodes might be "Good weather," "BBQs," "Vacation," "Air conditioning," and "School's out."įrom each node, you then repeat the process, drilling deeper into the different concepts. Then the fun starts: around your central theme, you create "nodes" connected by lines, each with its own related idea or theme. You start by writing a central idea or theme in the middle of a blank sheet of paper. ![]() Traditionally, a mind map is done with a pen (or, ideally, loads of colored pens) and paper. ![]() MindMeister for collaborating on a mind map with a teamĪyoa for a modern approach to mind mapping The 5 best mind mapping toolsĬoggle for mind map beginners and occasional use Pen and paper set a very high bar to clear, but these are the five best mind mapping apps that manage to clear it. I've also made dozens of mind maps myself, both on paper and digitally. Over the past several years of updating this list, I've tested close to 50 different mind map tools, many multiple times as they've been updated and added new features. (It's a weird hybrid approach, but it works for me.) I do most of my mind mapping digitally-and even when I don't, I often recreate a paper mind map online so that I can have it safely stored and easily searched. ![]() So, instead of asking for responses to be shared with the whole group: From the motif in western movies where the wind blows tumbleweeds through the scene, usually to establish that the place is. GIFs to laugh at the emptiness in the head, refrigerator or elsewhere. Do a think-pair-share – ask people to discuss possible responses with their neighbour.Ask for a show of hands, then do a follow up question directed to someone who raised their hand.Wild west scenes, real video reports of tumbleweed and much more. Some individuals struggle to find answers when put on the spot so ask everyone (including yourself) to write down a quick response.This breaks the ice and allows them to share what they thought collectively. Then ask if anyone would like to share what they wrote. Here you can flip the image (mirror) horizontally and vertically, and rotate (spin) it using presets or by entering freely chosen degrees, clockwise and counter-clockwise.(If no-one does, you can share what you wrote down). If you haven’t had a response to your question, you could suggest a possible answer yourself and then ask for agreement or disagreement within the group. This tool can rotate animated GIF, WebP, APNG and FLIF files, as well as images in any other well known. To get answers, you may need to put more effort into your question. Kanzuke Registered, Moderator Posts: 181. September 2013 edited October 2013 in Watercooler 1.į ollow my advice on How to Ask Brilliant Questions that Get Responses. If you still get zero responses, you will need to re-phrase your question (see below).Think about re-wording or re-phrasing your question differently. In this section you will find animated clipart and animations related to the topic of Animations. Lambda217: oh oh i am kanzuke and i love my little pony and now ill make all the brandonphysics myself cause i know fuckin everything because now ill make a big pony fighter drone squad and a big. Click on the Thumbnails to select ANIMATED GIF format. Maybe you included too much other information and your actual question got buried. So, when you re-phrase shorten the message and speak less. moving animation backgrounds animated backgrounds ,for websites windows ,desktop backgrounds,flashing gif,art graphics,pictures,photo,image,icon,videos. Or maybe your question was too vague and the group are not sure how to answer. Tumbleweed Tango Tumbleweed Tango from HUMBLE TV on Vimeo. In the Illustrations group of the Insert tab, click Pictures. Email This BlogThis Share to Twitter Share to Facebook Share to Pinterest. Choose This Device from the drop-down menu. Harnessing technologies openSUSE is renowned for, such as the Btrfs file-system, the snapper command-line utility as well as the battle-proven YaST control panel, Tumbleweed empowers you with full control over your system, letting you define the settings you want and be done with it. ![]() Locate and select the GIF you want to insert. ![]() No longer do you have to worry about a system. ![]() Rumble McSkirmish is a 16-bit video game character. The GIF will appear in your Microsoft Word document. He protects Dipper Pines from Robbie Valentino under the belief that Robbie had killed Dippers father, until Dipper confesses that he lied to Rumble. Later, during the events of Weirdmageddon, he becomes a sentient being and defects from Bill Ciphers regime for his attempt to destroy the universe and humanity. You’ll see a pause icon in the bottom-left corner of the image. And finally, never, ever ask ‘any questions?’ For more help with common mistakes when asking questions, read this. This is usually a guaranteed ‘tumbleweed moment’. Instead, ask a specific question, wait for the hands to go up and then ask that person a follow-up question. ![]() They won’t be able to move, delete, or edit the fields themselves until protection is turned off. When this option is enabled, the only change that anyone else can make to this document is the filling in of form fields. Feel free to download, modify, and use any you like. Click the Editing restriction list arrow. Weve put together a selection of the best free Word invoice templates for you. ![]() Check the Editing restrictions check box. Below, you’ll find a variety of work order templates, all of which are free to download, easy to use and customize, and printable.The Restrict Editing pane appears on the right. Click the Restrict Editing button on the Developer tab.Start by adding yourself, and then work your way through the generations. The PDF forms may be opened and filled out using the Adobe Reader free. Its a very basic chart with boxes, lines, and nothing fancy, but it gets the job done. When you’re ready to distribute a form so others can fill it out, you can restrict the form so that content controls cannot be removed or changed by those filling it out. Below, you’ll find a variety of work order templates, all of which are free to download, easy to use and customize, and printable. They are available as Microsoft Word document template forms and also as PDF forms. Users select a date and the control automatically formats the date’s appearance.Ĭontains the form controls from previous versions of Word. Users choose from several selections that appear by clicking the list arrow. Shows a gallery of formatted design choices from the Quick Parts gallery.Ĭreates a list that users can edit directly. A text input field that allows for rich text formatting.Ī text field limited to plain text, so no formatting can be included. ![]() File formats like PowerPoint, Excel or PDF remain the same but the file size is being reduced by as much as 90 percent according to Balesio. The tool optimizes the size of a file through restructuring - without alteration of its content. This is where Balesio Fileminimizer Suite comes into play. Also, our unmanned system purges all data after one hour, so you don’t need to worry about the security of your data.Īll uploaded data is deleted after 1 hour.Occasionally, sending large files over email can be slow or restricted by attachment size limits. Your original files will stay untouched on your system, so if you are unhappy with your compressed files, you can simply try again. There is no need to be worried about the safety of our free service. ![]() You can use this tool as many times as needed without cost. Ready for another batch? Hit the “CLEAR QUEUE” button and start again. If you don’t need all of them, you can hit the “DOWNLOAD” button under each thumbnail instead to grab each one individually. This will download a ZIP file with all your compressed images. When you are satisfied with the current batch, hit the “DOWNLOAD ALL” button. When you’re finished, hit the “APPLY” button and move on to repeat these steps with the next image. Now, move the quality slider up or down until you settle on a file size/quality setting you think is just right. Tap the thumbnail of the image you’d like to tweak. However, if you want more or less compression, you can control it. You’ll be able to see their real-time progress as our server analyzes them.Īs stated, our server will determine the ideal compression rate to reduce the file size while not reducing quality too much. Once uploaded, you’ll see thumbnails for all your images arriving in the queue. ![]() Our server can automatically parse out the files for you.įirst, hit the “Upload Files” button and navigate to your images. In other words, you don’t need to only upload JPGs and wait to upload PNGs. You can upload up to 20 images at once and you can feel free to mix and match file types. To begin, you’ll need to upload some images you’d like to compress. This system intelligently analyzes uploaded images and reduces them to the smallest possible file size without negatively affecting the overall quality. It supports three file types: PNG, JPG/JPEG, and GIF. Our tool uses lossy compression to shrink down image files. Compressing them could free up more internal storage, fixing this problem. These images could be taking up a lot of hard drive space and preventing you from taking more photos. Likewise, you might have large images on your phone. Compressing this image would be very useful. Depending on your needs, this could be too big. A JPG from a professional DSLR camera, for example, could be dozens of megabytes. Why would you want to compress images?ĭepending on the source of an image, the file could be quite large. With lossy compression, how small you want the final file to be will depend on how much loss of quality you’re comfortable with. This results in a smaller file but with a reduced quality. Lossy compression is when the compressor removes excessive or unimportant bits from the original file. This results in a smaller file that has the exact same quality as the original. Lossless compression is when the compression tool removes empty, needless, or duplicated bits from the original file. There are two types of compression: lossless and lossy. Simply put, it means converting a large file into a smaller file. In terms of digital files, compression is the act of encoding information using fewer bits than what’s found in the original file. Unpack the tent, unroll the tent body, and lay it out on the ground.Here’s how you set up the Eureka Tetragon NX2 tent: The package comes with 4 stakes, the tent body, the rainfly, the mainframe poles, and two fly poles. The Tetragon NX 2 person tent is a breeze to set up, even for one. Make sure the tent is completely dry before storage to prevent any mold or mildew.Ĭlean the tent poles and zippers with a dry cloth, especially if you have been camping in sand or near the sea. Clean the tent by wiping it down with mild soap and warm water, and rinse and dry completely.ĭon’t use any harsh detergents and chemicals or machine wash the tent as this could damage the protective coatings. You can prolong the lifespan of your Tetragon NX 2 person tent with some post-camping light maintenance. The lightweight, fiberglass 7.9mm tent poles and 6mm fly poles are more resistant to rust and corrosion, but will not stand up to inclement weather as well as the more expensive aluminum poles that higher-end tents use.įiberglass poles are typically used in entry-level tents but if you’re only camping a few times a year in fair weather, the significant price increase might not be able to justify a tent with aluminum poles. A higher “D” number would be thicker, stronger, and more durable. The “D” denotes “denier”, which is the unit of measurement for the thickness and weight of the threads in a fabric. The rainfly, floor, and walls are made of durable 63D polyester, while the mesh is made of 40D polyester. Overall, it stands up incredibly well to cold weather but might be a little uncomfortable on rainy days due to the slight lack of rain protection. It does, however, have a hooded rainfly to somewhat protect your main door from the wet.ĪLSO SEE: Best Camping Tents with a Hinged Door In addition, it stands up to strong winds and heavy rains well but doesn’t have a vestibule for you to stash muddy or wet boots or shoes in rainy weather. Even when it goes down to close to freezing, the tent stays relatively warm at night. The Tetragon NX 2 person tent performs remarkably well in cold and wet weather. Leaving the rainfly off is advisable in warmer weather, as the tent can get stuffy on still nights. While the back panel doesn’t have a window, there is a vent opening along the top for an added ventilation boost. However, the rainfly’s hooded design helps promote some airflow, and the two generous mesh windows keep the air circulating and the bugs out. ![]() The tent stays nice and airy with the rainfly off, but like most other tents, the polyester sheet inhibits airflow when in use. ![]() Dome tents also offer superior protection from the elements. Like all dome tents, the sloping walls take some shoulder room away but give maximum headroom and stability in higher winds and bad weather. There’s also a loop for a camping lantern. You can stash your camping essentials in the gear loft or the two storage pockets, while the two side windows give you plenty of airflow. There isn’t a vestibule, which is a bit of a downer, but there IS a hooded rain fly to keep the showers away from your main door. ![]() Like other 2-person tents, the peak height of 4 feet (1.2 meters) isn’t enough to stand upright but you’ll be able to comfortably move around in a crouch. Unlike other tent manufacturers, when Tetragon says two people, it really means two people, not one-and-a-dog. With an interior floor dimension of 7 ft x 5 ft (2.13m x 1.5m) and a floor space of 35 square feet (3.25 square meters), the Tetragon NX 2 person tent fits two people comfortably in a single room. white background in the Object Explorer, Results grid, etc.I absolutely love dark app themes. ![]() There might be some visual deviations e.g. Note: As I mentioned before, the SSMS Dark theme is not officially supported and it probably never be and that’s why it is disabled by default. Once either of those two methods is done, startup SSMS, and change the visual appearance to dark. There will be no return message that the operation succeeded except the blinking cursor on a new line. Powershell -Command "(gc 'C:\Program Files (x86)\Microsoft SQL Server\130\Tools\Binn\ManagementStudio\ssms.pkgundef') -replace '\' | Out-File 'C:\Program Files (x86)\Microsoft SQL Server Management Studio 18\Common7\IDE\ssms.pkgundef'" To run the PowerShell as an administrator, click Start, type PowerShell, right-click Windows PowerShell, and then choose Run as administrator:ĭepending on the version of SSMS, copy the appropriate script into the clipboard, paste it in PowerShell and hit Enter to execute it: So, in this example, Windows PowerShell is used. I’d go with the PowerShell because, in some cases, even upon successful execution of the script in Command Prompt, the changes are not applied (the case with SSMS 17.7). Either way, make sure to run the interpreter as an administrator or you’ll get an error message that access to the path is denied: Instead of doing the same steps to enable the SSMS Dark theme each time there is an upgrade, thanks to a reader (Luka Lovre) who made a PowerShell script, there’s an easier way with the same outcome which can be achieved in just a few clicks.Īll we need to do is to run either Command Prompt or Windows PowerShell which is designed to improve the command-line and scripting. This will, of course, overwrite the tweak we made earlier and the Dark theme will no longer be available in the options. Once completed, start SQL Server Management Studio and the Dark color theme will be available in the Color theme drop-down box:Įach upgrade of the latest generation of SSMS will set the configuration file back to its defaults. Once the file is opened in the text editor, scroll down and find the section of the code under the “Remove Dark theme” heading, add “//” (without quotation marks) at the beginning of the first line like shown below, and save the file: The configuration (ssms.pkgundef) file is located at the following locations:Ĭ:\Program Files (x86)\Microsoft SQL Server\130\Tools\Binn\ManagementStudioĬ:\Program Files (x86)\Microsoft SQL Server\140\Tools\Binn\ManagementStudioĬ:\Program Files (x86)\Microsoft SQL Server Management Studio 18\Common7\IDEĭepending on SSMS version, locate and open the configuration file (ssms.pkgundef) in the text editor: ![]() Run any text editor as an administrator, in this case, Notepad is used, in order to edit the SSMS configuration file: To enable the SSMS Dark theme, follow these simple steps.Ĭlose SSMS if it is running. The dark theme has been very popular among SQL database administrators and developers. ![]() In SSMS 2016, SSMS 2017 and the latest SSMS 18, the user can switch between the Blue or Light theme by going to Tools | Options | Environment | General | Color theme:Īlthough it’s not officially supported by Microsoft, the Dark theme is also available in SQL Server Management Studio 2016, 17, and the latest 18 version. In SQL Server Management Studio 2016, Microsoft introduced a visual setting option to choose between the Blue and Light color theme. ![]() In addition to offering thousands of audiobooks, a majority of Libby’s library is reserved for hosting e-books. Libby just makes a lot more financial sense, especially since there aren’t any late fees for overdue books. Contrast that with Libby’s free-for-all-library-card-holders approach, and one option just makes a lot more financial sense, especially since there aren’t any late fees for overdue books with Libby. In other words, the price of the service can add up quickly. Additionally, you’re paying not only for the book, but the price of your monthly Audible subscription - which can cost anywhere from $8 to $23 per month. While Audible can get you instant access to newly released audiobooks, you’ll be paying full price for them, and although the different Audible subscriptions can help you save when purchasing audiobooks, they certainly aren’t free. ![]() That, however, can be avoided with some simple communication and courtesy. My entire family of five splits a single account and never runs into an issue outside of potentially losing your place in an audiobook when someone else starts it. Sharing an account does mean that your number of rentable books needs to be split between you and whoever else is on the account, but Libby allows its users to borrow up to ten audiobooks at once. That said, if you’re like me and don’t have a library nearby, you can still sidestep the hundreds of dollars it can cost for a yearly subscription to Audible as long as you have a friend or family member with a library card who is willing to share their login information with you. People who live in areas without dedicated libraries won’t have access to it, which is worth keeping in mind if you’re trying to set up an account. Instead, you need to check out and reserve books as you would in a physical library.īecause Libby is tied to local libraries, it’s not an app that can be used by everyone. The app essentially works as an extension of your local library, meaning that you don’t necessarily have unlimited access to the content on it. Libby allows users to access thousands of audiobooks, including new releases, for absolutely no charge. Libby is an audiobook and e-book app that’s connected to libraries across the country. Luckily, it doesn’t have to be that way, thanks to Libby. That sentiment is what caused me (and many other users) to stick with it for years despite having to pay a small fortune just to stay current with the latest releases. To me, Audible always felt like an app that was about as good as an audiobook app could be because of how much better it is than things like Spotify’s audiobook offerings, despite Audible’s major flaws and high price. While it’s an overall decent service, Audible is hindered by plenty of paywalls and restrictions - regardless of which type of Audible subscription you have. It’s owned by Amazon, so there’s big money behind it, making the app nearly inescapable. I love being able to take in a novel while doing other things - blogging, driving around, doing laundry, working off the pinot grigio at the gym.It feels safe to say that Audible is the most popular app for those looking to get into audiobooks. That said, I'm 100% an audiobook aficionado (of course all the books I list below are available as "normal" books, as well). ![]() And, since we're always going to England, English mystery novels perform double duty for me! I also find reading to be a great way to prepare for/get in the mood for a trip - no matter where we're going, I load up on books about the newest location. ![]() From the first time I read And Then There Were None in lower school, I haven't been able to stop searching for my next "favourite" English detective.īeing lawyers (or a recovering lawyer and now blogger, in my case), my husband and I read all day at work, but I also love books. In Unicode, the Clear key is represented by U+2327 ⌧ X IN A RECTANGLE BOX, defined as "clear key". A Clear key, instead of a Num Lock key, on models with full numeric keypads, as these are dedicated to numeric input and not generally used for cursor control.Compact keyboards such as the bluetooth wireless aluminium keyboard and the built-in keyboards on all Intel-based Macintosh notebooks range from F1-F12 only, just like IBM PC keyboards. F17-F19 keys were introduced with the aluminium USB keyboard. Full-sized desktop keyboards with a dedicated numpad have function keys that can range up to F15, F16, or F19.Compared to their equivalents on the standard IBM PC keyboard layout the Command key and the Option key are located in reverse order. It functions as the Alt key in Unix and Windows environments. It serves the function of the solid-Apple key in Apple II applications. Like the Shift and Control keys, the Option key serves as a modifier for the Command key shortcuts, as well as being used to type many special characters. The Option key ( ⌥), for entering diacritics and other special characters.The open-Apple key was combined with the Command key on Apple Desktop Bus keyboards (which were used on both the Apple IIgs and several years of Macintosh models) where it remained after the Apple II line was discontinued. The "open" (hollow) and separate "closed" (solid) Apple logo keys on the Apple II series, served functions similar to that of the Command key.The key functions as a Meta key or Super key in Unix-like environments, and is equally equivalent to the Windows key in Windows environments, although in common applications it performs the same function as the Windows Control key. The Command key ( ⌘), used in most Mac keyboard shortcuts.Features different from other keyboards include: Some of these keys have unique symbols defined in the Unicode block Miscellaneous Technical. To serve the functionality of the Macintosh operating systems (and because of historical differences), the Apple Keyboard's layout differs somewhat from that of the ubiquitous IBM PC keyboard, mainly in its modifier and special keys. ![]() Shrieking after losing a mate seems understandable, but the action of the robin was something I've never witnessed, before or since." A nearby robin flew over and perched right next to the cardinal, as if to comfort her. Note to readers: Dick Adair of Minneapolis was interested in a recent piece about birds and grief and described what happened when a free-range cat snatched a male cardinal out of his birdbath: "His mate flew up to a power line and made very loud and seemingly anguished shrieks. Some newer varieties of crabapple were developed for cold hardiness and bloom, and their fruit hangs on the tree longer, providing winter meals for robins, waxwings and other birds. Could all the crabapple trees planted in people's yards be a factor?Ī: Good question, and yes, many more robins are staying around all winter, surviving primarily on fruit, such as crabapples and berries. Q: I'm intrigued by the fact that many robins skip migration and stay in our area all winter. When all the worms are hibernating, robins relish crabapples and other fruits. They're nearly invisible to humans, but stand out for birds. These are available at wild bird stores and online, and they do save lives. I like to use the UV reflectant decals manufactured by WindowAlert. Q: Tell me again the name of those decals that help prevent birds from running into windows?Ī: Sure, happy to, because so many birds die after flying into our home windows. And if one member of a cardinal pair dies, the other will quickly look for a new partner. But some cardinals aren't all that different from humans: Most stay together as long as they both live, but some seek out a new mate, even if it's during nesting season. Instead, they typically remain together all year long. But what if something happens to one or the other of the pair?Ī: Cardinal pairs don't separate after nesting season, as many songbirds do. I've read that this is part of their courtship. Q: Do cardinals mate for life? I've been watching a pair in my backyard, with the male feeding the female a seed or some other foods. This very well could have been the work of a male owl bringing food to his mate as she sat on eggs or to tiny owls in their nest in early March. And great horned owls are notorious for dismembering their prey and stashing some for later consumption. It would have to be a large owl, in order to carry a relatively heavy rabbit up to your second story. Did a raptor do this, and if so, what kind? It was gone the next day.Ī: This sounds like the work of a great horned owl. Q: A strange scene at our house the other day: Looking out a second-floor window, we spied half of a large rabbit (the head and upper body seemed to be missing) in the rain gutter. Tune in to Journey North to plot hummingbirds' progress from south to north. In addition to your feeder, you could place a hanging basket of flowering plants nearby, to catch their eye and provide another source of nectar. Q: When should I put out my hummingbird feeders?Ī: The first of these tiny dynamos should appear in late April, but look for most of these little migrants around mid-May. |